Photochemical properties and photocytotoxicities against wound bacteria of sulfanyl porphyrazines with bulky peripheral substituents

Porphyrazine macrocycles with bulky peripheral phenylalkylsulfanyl substituents were subjected to photochemical studies. The singlet oxygen generation potential of these was assessed using an indirect method DPBF and all molecules revealed low quantum yields up 0.03. In the photostability study, porphyrazine derivatives underwent photobleaching processes under light irradiation 2.45 ∙ 10−5. photocytotoxicities sulfanyl researched in liposomal nanoparticles against wound bacteria, such as Staphylococcus aureus, methicillin-resistant aureus (MRSA), epidermidis, Streptococcus pyogenes. most active appeared magnesium(II) porphyrazines 5-(3,5-dibutoxycarbonylphenoxy)pentylthio- 2-[2-(3,5-dibutoxycarbonylphenoxy)ethoxy]ethylthio-substitents. According calculated photokilling rates obtained photoinactivation greatest reduction bacterial growth 4.7 log noted for S. pyogenes, whereas moderate activity 2.5–2.6 observed aureus. Low or no photocytotoxicity studied MRSA epidermidis.